Simon Melov, PhD, heads the Buck Institute’s Genomic Core, which explores the role of the energy-making units inside cells, the mitochondria. Simon’s research focus is in identifying molecular hallmarks of aging to guide the development of anti-aging therapies.
Melov received his PhD in Biochemistry from the University of London in the UK. He held positions at Emory University in Atlanta and at the University of Colorado in Boulder before joining the faculty of the Buck Institute as an associate professor in 1999.
Other research interests include the age-related bone disorder osteoporosis, age-related heart disease, the role of methylation in the aging human genome, and developing molecular techniques to better understand single cell changes with age.
In a landmark study, Melov and collaborators showed that the more vigorous pattern of gene expression found in young adults could be partially restored in older adults who followed a strength training exercise program for 6 months.
Near the beginning, Simon talks about the impressive number of muscle biopsies carried out by Dr. Mark Tarnopolsky. The audio drops out for a nano-second when Simon says at least 20,000!
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- The benefits of resistance training for health and anti-aging
- What exercise is considered optimal for health-span and longevity?
- The pros and cons of rodent-based studies
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Selected Links from the Episode
- Resistance Exercise Reverses Aging in Human Skeletal Muscle
- Exercise: The Real Cure For Aging
- The One-Minute Workout: Science Shows a Way to Get Fit That’s Smarter, Faster, Shorter by Dr. Martin Gibala with Christopher Shulgan ( Amazon US / Amazon UK )
- Nautilus, Inc.
- McMaster University
- The One-Minute Workout Designed by Scientists — Dr. Martin Gibala (The Tim Ferriss Show)
- Standing Desk ( Amazon US / Amazon UK )
- Dr. Teresa Liu-Ambrose on The Cognitive Health Benefits of High Intensity Training